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Diazepam (Valium) is a tranquilizer, benzodiazepine derivative, which has anxiolytic, sedative, anticonvulsant, central myorelaxing action. Indications to the drug application: neuroses, psychopathy, schizophrenia, and insomnia, epilepsy, itching dermatosis. Contraindications: severe myasthenia gravis, severe chronic hypercapnia; alcohol or drug dependence in the history (except for acute withdrawal); hypersensitivity to Diazepam and other benzodiazepines, pregnancy.

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Diazepam is a tranquilizer, benzodiazepine derivative, has anxiolytic, sedative, anticonvulsive, central muscle relaxing effects. The mechanism of action associated with increased braking power GABA in the CNS. Muscle relaxing effect is due to the inhibition of the spinal reflexes. Lorazepam can cause anticholinergic effect.

Pharmacokinetics

Absorption is rapid. Maximal concentration in plasma is observed after 90 minutes. Linking plasma protein is 98%. Diazepam penetrates through the placental barrier, into the cerebrospinal fluid is excreted in breast milk, metabolized in the liver, excreted by kidneys (70%).

Dosage

Lorazepam is taken orally, intramuscularly, intravenously, rectally. A daily dose varies from 500 mcg up to 60 mg. A single dose, frequency and duration of application should be set individually.

Pregnancy and lactation

You shouldn't take Diazepam in the first trimester of pregnancy, except in cases of extreme necessity. You should take into account should that Valium using in pregnancy may cause significant changes of the fetus heart rate.

Using in obstetrics doses is recommended for ease childbirth, newborn, often in premature infants: temporary muscle hypotension, hypothermia, and respiratory failure are possible.

Breastfeeding should be discontinued in the regularly drug taking.

Avoid Diazepam using for newborns, as they haven't formed enzyme system, participated in the metabolism.

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