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Zithromax is antibacterial drug wide spectrum of action, is an antibiotic of macrolide group. Zithromax is used for the treatment of infections of the respiratory tract and ENT-organs infections of the skin and subcutaneous adipose tissue, infections of the urinary tract and genital organs.

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Zithromax is a new antibiotic from the macrolides (azalides) group. The drug is highly effective against both gram-positive microorganisms, including beta-laktamase producing (staphylococci, streptococci, pneumococci), and gram-negative microorganisms (enterococci, E. and H. influenzae wand, Shigella, Salmonella), and Mycoplasma, Legionella, and Bacteroides. In high concentrations Zithromax has bactericidal activity, active against a number of diseases, sexually transmitted infections (gonococci, Trichomonas, chlamydia, spirochete). Zithromax is used in diseases caused by susceptible to malaria microorganisms, including sore throat, scarlet fever, otitis, pneumonia, bronchitis, erysipelas, infected dermatitis, urethritis and other infectious diseases. The drug is effective when taking inside. It is possible allergic reactions, nausea, vomiting.

Zithromax is stable in the acidic environment, lipophilic, in oral administration absorbed rapidly from the gastrointestinal tract. After a single intake of 500 mg bioavailability is 37% (effect of «first pass»), Cmax (0.4 mg/l) is 2-3 hours, the apparent volume of distribution - 31.1 l/kg, linking protein inversely proportional to the concentration in the blood and is 7-50%, T1/2 - 68 hours. Stable level of plasma is achieved in 5-7 days. The medicine is easily passes histohematogenous barriers and enters the tissue, is transported also by phagocytes, polymorphonuclear leukocytes and macrophages to the infection area, which released in the presence of bacteria; penetrates through the cell membrane (effective in infections caused by intracellular pathogens). Concentration in the tissues and cells is 10 to 50 times higher than in plasma, and in the nidus of infection on 24-34% more than in healthy tissues. High level (antibacterial) stored in the tissues during the 5-7 days after the last injection. Food intake significantly alters the pharmacokinetics (depending on the drug form) capsules - decreased Cmax (52%) and AUC (43%); suspension increases in Cmax (46%) and AUC (14%); tablets - increases in Cmax (31%), no change in AUC. The drug is dimethylized in the liver, losing activity. Plasma clearance is 630 ml/minute. 50% is excreted with bile in an unmodified form, 6% - from urine. In the older men (65-85 years old) pharmacokinetic parameters can be changed, in women Cmax increases (on 30-50%); in children aged 1-5 years old Cmax, T1/2 and AUC decrease.

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